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The immunomodulatory effects of tachykinins and their receptors

Sahar Khorasani1, Nadia Boroumand2,3, Fahimeh Lavi Arab4

  • 1Ferdows Paramedical School, Birjand University of Medical Sciences, Birjand, Iran.

Journal of Cellular Biochemistry
|March 3, 2020
PubMed

Tachykinins (TKs) are a family of neuropeptides mainly expressed by neuronal and non-neuronal cell types, especially immune cells. Expression of TKs receptors on immune cell surfaces, their involvement in immune-related disorders, and therefore, understanding their immunomodulatory roles have become of particular interest to researchers. In fact, the precise understanding of TKs intervention in the immune system would help to design novel therapeutic approaches for patients suffering from immune disorders. The present review summarizes studies on TKs function as modulators of the immune system by reviewing their roles in generation, activation, development, and migration of immune cells. Also, it discusses TKs involvement in three main cellular mechanisms including inflammation, apoptosis, and proliferation.

Keywords:
immune systemimmunomodulationtachykinintachykinin receptor

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