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Current and emerging biologics for the treatment of juvenile idiopathic arthritis

Rolando Cimaz1,2, Gabriella Maioli3, Giulia Calabrese3

  • 1Pediatric Rheumatology Department, ASST-Gaetano Pini-CTO, Department of Clinical Sciences and Community Health, University of Milan , Milan, Italy.

Expert Opinion on Biological Therapy
|March 3, 2020
PubMed

Insights

This review discusses biologic therapies for juvenile idiopathic arthritis (JIA), focusing on current treatments and emerging drugs. It highlights the need for targeted approaches to control inflammation and achieve remission effectively.

Area of Science:

  • Pediatric Rheumatology
  • Immunology
  • Pharmacology

Background:

  • Juvenile idiopathic arthritis (JIA) management requires integrated therapies to control inflammation and achieve remission.
  • Advances in understanding JIA pathogenesis have identified specific targets for biologic therapies.

Purpose of the Study:

  • To comprehensively review current biologic therapies for JIA.
  • To discuss emerging biologic drugs and their potential role in JIA treatment.
  • To consider clinical evidence, recommendations, and pharmacoeconomic factors.

Main Methods:

  • Systematic literature review of PubMed (January 1997 - January 2020).
  • Inclusion of national and international guidelines, recommendations, clinical trials, and case-control studies.

Main Results:

  • A wide range of biologic therapies targeting various pathways are available for JIA.
  • Physicians must select appropriate medications for early, sustained remission with minimal side effects.
  • Ongoing research aims for more specific suppression of inflammatory pathways.

Conclusions:

  • Biologic therapies offer targeted treatment options for JIA, with continuous advancements.
  • Personalized medicine and pharmacoeconomic evaluations are crucial for optimal JIA management.
  • Emerging biologic drugs hold promise for future JIA treatment strategies.
Abstract

Keywords:
Juvenile idiopathic arthritisbiologic therapyclinical evidencepediatric rheumatology

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