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Related Experiment Video

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Study Protocol: Transitions in Adolescent Girls (TAG).

Marjolein E A Barendse1, Nandita Vijayakumar1,2, Michelle L Byrne1

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Summary

The Transitions in Adolescent Girls (TAG) study investigates how puberty, brain development, and social factors impact adolescent mental health in girls. Findings will identify early risk factors for mental illness, aiding prevention strategies.

Keywords:
MRIadolescencehormoneslongitudinalmental healthpubertyself-developmentsocial processes

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Adolescent Health

Background:

  • Limited understanding of pathways linking pubertal and neurodevelopmental processes to adolescent mental health.
  • Adolescent depression and anxiety disorders emerge during a critical developmental period.
  • The Transitions in Adolescent Girls (TAG) study addresses this knowledge gap.

Purpose of the Study:

  • To investigate the complex relationships between pubertal development, brain structure/connectivity, and mental health in female adolescents.
  • To understand the neural and behavioral correlates of social and self-perception processes during adolescence.
  • To identify mechanisms underlying the emergence of mental illness in adolescent girls.

Main Methods:

  • Longitudinal study of 174 female adolescents (ages 10-13) over 3 years.
  • Multi-modal assessments including hormone/immune factors, MRI (structural, diffusion, fMRI), diagnostic interviews (K-SADS), self-narrative videos, and physical measurements.
  • Surveys on pubertal development, mental health, social environment, life events, self-perception, and social-emotional functioning.

Main Results:

  • Data collection ongoing, with the third wave of assessments currently underway.
  • Analysis will focus on developmental trajectories of pubertal, neurological, and social processes.
  • Identifying how these processes interact to predict mental illness onset.

Conclusions:

  • The study will elucidate developmental pathways and mechanisms predicting mental illness in female adolescents.
  • Findings will help identify modifiable, developmentally specific risk factors.
  • Knowledge gained will inform early intervention and prevention efforts for adolescent mental health.