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Mycophenolate-induced Colitis: A Case Report with Focused Review of Literature

Rehan Farooqi1, Afrin Kamal2, Carol Burke2

  • 1Internal Medicine, Medstar Union Memorial Hospital, Baltimore, USA.

Cureus
|March 3, 2020
PubMed

Insights

Mycophenolate mofetil (MMF) can cause colitis, a serious gastrointestinal side effect. This case report highlights the diagnostic challenges and management difficulties associated with MMF-induced colitis.

Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Mycophenolate mofetil (MMF) is a key immunosuppressant for autoimmune diseases and transplants.
  • Gastrointestinal adverse events, including diarrhea and colitis, are common MMF side effects.

Observation:

  • A patient developed colitis, diagnosed via colonoscopy and histopathology.
  • Managing MMF-induced colitis presents significant clinical challenges.

Findings:

  • MMF-induced colitis is a rare but significant complication.
  • Discontinuation of MMF leads to resolution in most diarrhea cases, but colitis management data is limited.

Implications:

  • This case underscores the need for increased awareness and diagnostic vigilance for MMF-induced colitis.
  • Further research is needed to establish optimal treatment strategies for MMF-induced colitis.
Keywords:
colitiscrypt cell apoptosisdrug induced colitisinflammatory bowel disease (ibd)mycophenolate induced colitisulcerative colitis

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