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Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Imaging Studies III: Computed Tomography01:27

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DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
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Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Related Experiment Video

Updated: Dec 27, 2025

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound
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Advanced Cancer Imaging Applied in the Comparative Setting.

David M Vail1,2, Amy K LeBlanc3, Robert Jeraj2,4

  • 1Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States.

Frontiers in Oncology
|March 3, 2020
PubMed
Summary

Companion animals with naturally occurring tumors offer a superior preclinical model for advanced cancer imaging technologies. Their size and biology better mimic human cancers than rodent models, accelerating clinical translation.

Keywords:
PET/CTbiomarkerscancercaninecomparativeimagingradiomicstheranostics

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Area of Science:

  • Comparative oncology
  • Preclinical cancer imaging research
  • Translational cancer research

Background:

  • Companion animals develop spontaneous tumors, offering a natural model for cancer research.
  • Existing murine models have limitations in replicating human cancer's size, metastasis, and tumor microenvironment.

Purpose of the Study:

  • To review the utility of companion animals as surrogates for preclinical cancer imaging technology development.
  • To highlight the advantages of companion animal models over rodent models for imaging research.

Main Methods:

  • Review of comparative cancer imaging approaches in companion species.
  • Discussion of key topics including consortia, quality assurance, biomarker development, and novel imaging applications.

Main Results:

  • Companion animal models offer better recapitulation of human cancer conditions due to natural tumor evolution and intact immune systems.
  • Standardization and harmonization of imaging protocols are facilitated by similar body size and anatomy.

Conclusions:

  • Companion animals provide a more relevant preclinical model for advanced cancer imaging, accelerating the clinical integration of new technologies.
  • This approach enhances the predictive value of preclinical data for human cancer treatment.