Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

615
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
615

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oral reference doses (RfDs) for sodium tungstate dihydrate.

Regulatory toxicology and pharmacology : RTP·2026
Same author

Estimating safe doses of perfluorooctane sulfonate (PFOS): an international collaboration.

Archives of toxicology·2025
Same author

Editorial: Next generation chemical risk assessment: integration of advances in toxicology, biology and computation.

Frontiers in toxicology·2024
Same author

Response to letter to editor "letter to the editors regarding "the Conundrum of the PFOA human half-life, an international collaboration."

Regulatory toxicology and pharmacology : RTP·2022
Same author

The Relationship Between Professionalism and Leadership: Parent-Child or Sibling?

Physical therapy·2022
Same author

The Conundrum of the PFOA human half-life, an international collaboration.

Regulatory toxicology and pharmacology : RTP·2022

Related Experiment Video

Updated: Dec 27, 2025

Evaluating the Effect of Pesticides on the Larvae of the Solitary Bees
05:13

Evaluating the Effect of Pesticides on the Larvae of the Solitary Bees

Published on: October 15, 2021

2.5K

A commentary on some epidemiology data for chlorpyrifos.

Michael Dourson1, Bernard Gadagbui1, Chijioke Onyema1

  • 1Toxicology Excellence for Risk Assessment (TERA), 1250 Ohio Pike, Suite 197, Amelia, OH, 45102, United States.

Regulatory Toxicology and Pharmacology : RTP
|March 3, 2020
PubMed
Summary

This study questions findings on prenatal chlorpyrifos (CPF) exposure and child neurodevelopment. The lack of accessible data and inconsistent results raise concerns about transparency in environmental health research.

Keywords:
ChlorpyrifosChlorpyrifos-oxonCholinesterase inhibitionFull-scale IQ scoresScience transparencyWorking memory index

More Related Videos

Determination of the Absorption, Translocation, and Distribution of Imidacloprid in Wheat
06:11

Determination of the Absorption, Translocation, and Distribution of Imidacloprid in Wheat

Published on: April 28, 2023

2.2K
Analysis of Organochlorine Pesticides in a Soil Sample by a Modified QuEChERS Approach Using Ammonium Formate
04:17

Analysis of Organochlorine Pesticides in a Soil Sample by a Modified QuEChERS Approach Using Ammonium Formate

Published on: January 20, 2023

3.7K

Related Experiment Videos

Last Updated: Dec 27, 2025

Evaluating the Effect of Pesticides on the Larvae of the Solitary Bees
05:13

Evaluating the Effect of Pesticides on the Larvae of the Solitary Bees

Published on: October 15, 2021

2.5K
Determination of the Absorption, Translocation, and Distribution of Imidacloprid in Wheat
06:11

Determination of the Absorption, Translocation, and Distribution of Imidacloprid in Wheat

Published on: April 28, 2023

2.2K
Analysis of Organochlorine Pesticides in a Soil Sample by a Modified QuEChERS Approach Using Ammonium Formate
04:17

Analysis of Organochlorine Pesticides in a Soil Sample by a Modified QuEChERS Approach Using Ammonium Formate

Published on: January 20, 2023

3.7K

Area of Science:

  • Environmental toxicology
  • Neurodevelopmental toxicology
  • Risk assessment

Background:

  • Chlorpyrifos (CPF) exposure is linked to critical effects on blood enzymes, informing regulatory safe dose determinations.
  • Previous studies suggested neurodevelopmental deficits in children from prenatal CPF exposure at low levels.
  • Data transparency is crucial for validating environmental health research findings.

Purpose of the Study:

  • To re-evaluate the association between prenatal chlorpyrifos exposure and neurodevelopmental outcomes in children.
  • To address concerns regarding data accessibility and transparency in published environmental health studies.

Main Methods:

  • Extracted and analyzed data from figures in Rauh et al. (2011).
  • Plotted extracted data as response versus log dose, a standard risk assessment approach.
  • Attempted to replicate reported associations between prenatal CPF levels and cognitive function.

Main Results:

  • A significant portion of the data from Rauh et al. (2011) was not found in the published figures.
  • The reported associations between chlorpyrifos levels and Working Memory or Full Scale IQ were not replicated in this analysis.
  • Multiple requests for raw data access were made but not fulfilled.

Conclusions:

  • The lack of data transparency and inconsistencies with other research raise concerns about the validity of findings on CPF and neurodevelopment.
  • Further investigation with accessible data is needed to confirm the effects of low-level prenatal chlorpyrifos exposure on child development.