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Updated: Dec 27, 2025
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
Published on: June 2, 2023
Evaluation of the 8th Edition TNM Classification for Anaplastic Thyroid Carcinoma
Naoyoshi Onoda1,2, Iwao Sugitani1,3, Ken-Ichi Ito1,4
1Anaplastic Thyroid Carcinoma Research Consortium of Japan, Tokyo 113-8603, Japan.
Background:
The tumor-node-metastasis (TNM) classification system to categorized anaplastic thyroid cancer (ATC) was revised.
Methods:
The revised system was evaluated using a large database of ATC patients.
Results:
A total of 757 patients were analyzed. The proportion and median overall survival values (OS: months) for each T category were T1 (n = 8, 1.1%, 12.5), T2 (n = 43, 5.7%, 10.9), T3a (n = 117, 15.5%, 5.7), T3b (n = 438, 57.9%, 3.9), and T4 (n = 151, 19.9%, 5.0). The OS of the N0 and N1 patients were 5.9 and 4.3, respectively (log-rank p < 0.01). Sixty-three (58.3%) patients migrated from stage IV A to IV B by revision based on the existence of nodal involvement and 422 patients (55.7%) were stratified into stage IV B, without a worsening of their OS (6.1), leaving 45 patients (5.9%) in stage IV A with fair OS (15.8). The hazard ratios for the survival of the patients of stage IV B compared to stage IV A increased from 1.1 to 2.1 by the revision. No change was made for stage IV C (n = 290, 38.8%, 2.8).
Conclusion:
The revised TNM system clearly indicated the prognoses of ATC patients by extracting rare patients with fair prognoses as having stage IV A disease and categorized many heterogeneous patients in stage IV B.
