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Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
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Panel-negative strategy for suspected fusion-driven papillary thyroid carcinoma.

Yoichiro Okubo1, Ikki Takada2, Mei Kadoya3

  • 1Kanagawa Cancer Center, Department of Pathology, 2-3-2 Nakao, Asahi-ku, Yokohama, Kanagawa, 241-8515, Japan. yoichiro0207@hotmail.com.

Thyroid Research
|June 6, 2026
PubMed
Summary

Molecular testing for thyroid nodules and papillary thyroid carcinoma (PTC) is crucial when results impact treatment. A new framework helps interpret limited test results, especially when suspicion for fusion-driven PTC persists, ensuring appropriate molecular testing.

Area of Science:

  • Oncology
  • Molecular Diagnostics
  • Genetics

Background:

  • Molecular testing for thyroid nodules and papillary thyroid carcinoma (PTC) is vital for treatment decisions.
Keywords:
Decision frameworkGene fusionMolecular diagnosticsPan-TRKPapillary thyroid carcinomaRNA-based fusion assay

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  • Limited assays may not detect clinically relevant fusions, leading to potential misinterpretation.
  • Existing workflows may not adequately address fusion detection in PTC.