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Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers.

Leela Goel1,2, Xiaoning Jiang1

  • 1Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695-7910, USA.

Sensors (Basel, Switzerland)
|March 4, 2020
PubMed
Summary

Sonothrombolysis uses ultrasound to break up blood clots, offering a promising alternative to traditional treatments. Advanced techniques show potential to overcome current safety limitations for improved clinical application.

Keywords:
high intensity focused ultrasoundhistotripsyintravascular ultrasoundmicrobubblessonothrombolysisultrasound contrast agentsultrasound enhanced thrombolysis

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Area of Science:

  • Biomedical Engineering
  • Medical Physics
  • Cardiovascular Research

Background:

  • Sonothrombolysis, an ultrasound-based method, is a key advancement for treating blood clots.
  • Existing techniques like transcranial Doppler and microbubble-mediated sonothrombolysis show clinical promise but have safety limitations.
  • Conventional thrombolytic treatments and mechanical thrombectomy are current standards of care for blood clots.

Purpose of the Study:

  • To review recent preclinical advancements in sonothrombolysis techniques.
  • To evaluate the strengths and limitations of novel sonothrombolysis approaches.
  • To assess the potential of these advancements to enhance clinical blood clot treatments.

Main Methods:

  • Review of recent preclinical research on sonothrombolysis.
  • Analysis of emerging techniques including targeted microbubbles, phase change nanodroplets, high-intensity focused ultrasound, histotripsy, and advanced intravascular transducers.
  • Evaluation of safety and efficacy data from preclinical studies.

Main Results:

  • Novel sonothrombolysis techniques demonstrate potential to address limitations of conventional methods.
  • Advancements such as targeted drug delivery and focused ultrasound show promise for enhanced clot dissolution.
  • Preclinical data suggests improved safety profiles for newer sonothrombolysis approaches.

Conclusions:

  • Recent preclinical advancements in sonothrombolysis offer significant potential to improve blood clot treatment.
  • These innovative techniques may overcome safety and efficacy challenges associated with current therapies.
  • Further research and clinical translation are warranted to realize the full potential of advanced sonothrombolysis.