Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

6.8K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.8K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

413
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
413

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of a PET Insert for Trimodal Imaging: A Step Toward PET/MRI-Guided Focused Ultrasound.

IEEE transactions on radiation and plasma medical sciences·2026
Same author

Transformer-based AI approach to unravel long-term, time-dependent prognostic complexity in patients with advanced NSCLC and PD-L1 ≥50%: insights from the pembrolizumab 5-year global registry.

Journal for immunotherapy of cancer·2025
Same author

Integrated molecular and clinical characterization of pulmonary large cell neuroendocrine carcinoma.

Nature communications·2025
Same author

Molecular and immunological features associated with long-term benefits in metastatic NSCLC patients undergoing immune checkpoint blockade.

Oncoimmunology·2025
Same author

Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y global registry.

Journal for immunotherapy of cancer·2025
Same author

Exploring the value of routinely collected data on EQ-5D-5L and other electronic patient-reported outcome measures as prognostic factors in adults with advanced non-small cell lung cancer receiving immunotherapy.

BMJ oncology·2025

Related Experiment Video

Updated: Dec 27, 2025

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

4.1K

Simulation Study for Designing a Dedicated Cardiac TOF-PET System.

Sandra Oliver1, Laura Moliner1, Víctor Ilisie1

  • 1Instituto de Instrumentación para Imagen Molecular (i3M) Centro mixto CSIC - Universitat Politècnica de València. Camí de Vera s/n, 46022 València, Spain.

Sensors (Basel, Switzerland)
|March 4, 2020
PubMed
Summary

Optimizing cardiac positron emission tomography (PET) systems requires careful geometry selection. A time-of-flight (TOF) resolution of approximately 200 picoseconds is crucial for minimizing image artifacts in open PET geometries.

Keywords:
PET imagingdedicated cardiac systempositron emission tomography (PET)

More Related Videos

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.7K
A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

8.9K

Related Experiment Videos

Last Updated: Dec 27, 2025

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

4.1K
Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.7K
A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
14:19

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

8.9K

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Biomedical Engineering

Background:

  • Dedicated positron emission tomography (PET) systems enhance lesion detection for cancer care.
  • Open PET geometries can introduce image distortions and artifacts.
  • Novel cardiac PET system development necessitates optimizing geometry and time resolution.

Purpose of the Study:

  • Determine the optimal geometry for a new cardiac PET system.
  • Establish the required time-of-flight (TOF) resolution for acceptable image quality.
  • Evaluate the impact of TOF resolution on image artifacts in open cardiac PET.

Main Methods:

  • Simulated 36-module cardiac PET system with varying configurations.
  • Employed Monte Carlo simulations to assess image quality.
  • Tested multiple time-of-flight (TOF) resolutions.

Main Results:

  • Increasing TOF resolution demonstrably reduces image distortion and artifacts.
  • Specific geometric configurations were evaluated for their impact on image quality.
  • A TOF resolution around 200 picoseconds significantly mitigates artifacts.

Conclusions:

  • A TOF resolution of approximately 200 ps is necessary for high-quality cardiac PET imaging with open geometries.
  • Optimal geometry and TOF resolution are critical for reliable lesion detection in cardiac PET.
  • This research informs the design of advanced cardiac PET scanners.