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Chronodisruption: A Poorly Recognized Feature of CKD
Sol Carriazo1,2, Adrián M Ramos1,2, Ana B Sanz1,2
1IIS-Fundacion Jimenez Diaz, Department of Medicine, Universidad Autonoma de Madrid, Fundacion Renal Iñigo Alvarez de Toledo-IRSIN, 28040 Madrid, Spain.
Toxins
|March 4, 2020
Summary
Chronic disruption of biological rhythms, known as chronodisruption, impacts kidney health. This review explores chronodisruptors in chronic kidney disease (CKD) and their therapeutic potential.
Area of Science:
- Physiology
- Chronobiology
- Nephrology
Background:
- Biological rhythms, including circadian rhythms, are crucial for normal kidney function.
- Chronodisruption, the chronic disturbance of these rhythms, is linked to disease development.
- The kidney possesses active peripheral biological clocks, making it susceptible to chronodisruption.
Purpose of the Study:
- To comprehensively review chronodisruption and chronodisruptors in chronic kidney disease (CKD).
- To examine the impact of chronodisruption on CKD manifestations.
- To identify potential chronodisruptors, including uremic toxins, as therapeutic targets in CKD.
Main Methods:
- Literature review of studies on circadian rhythms, chronodisruption, and CKD.
- Analysis of evidence linking altered circadian rhythms to CKD progression.
- Identification and discussion of potential chronodisruptors relevant to CKD.
Main Results:
- Evidence suggests circadian rhythms are altered in CKD and may accelerate disease progression.
- Chronodisruptors, some of which are uremic toxins, are implicated in CKD.
- The term chronodisruption has been underutilized in the context of CKD.
Conclusions:
- Chronodisruption significantly impacts kidney physiology and CKD progression.
- Identifying and targeting chronodisruptors may offer novel therapeutic strategies for CKD patients.
- Further research is needed to fully understand and address chronodisruption in CKD.
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