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The role of programed death-ligand 1 in renal diseases

Yi Wei1, Zongpei Jiang1

  • 1Department of Nephrology, The Sixth affiliated hospital, Sun Yat-sen University, Guangzhou, China.

Journal of Receptor and Signal Transduction Research
|March 4, 2020
PubMed

Insights

Programmed death-ligand 1 (PD-L1) impacts kidney diseases. This review clarifies PD-L1

Area of Science:

  • Immunology
  • Nephrology
  • Molecular Biology

Background:

  • Programmed death-ligand 1 (PD-L1) is a key coinhibitory molecule implicated in various diseases.
  • The specific roles of PD-L1 in primary and secondary renal diseases require further elucidation.
  • Both intracellular and intercellular PD-L1 mechanisms are involved in renal pathology.

Purpose of the Study:

  • To comprehensively review and summarize existing literature on the role of PD-L1 in renal diseases.
  • To clarify the complex mechanisms by which PD-L1 influences kidney pathology.
  • To highlight potential therapeutic applications of targeting PD-L1 in renal conditions.

Main Methods:

  • Systematic literature review of studies investigating PD-L1 in renal diseases.
  • Analysis of data on PD-L1's involvement in different types of nephritis and kidney injuries.
  • Evaluation of evidence regarding therapeutic strategies targeting PD-L1.

Main Results:

  • PD-L1 exhibits a dual role in lupus nephritis.
  • PD-L1 demonstrates a protective effect in renal ischemia reperfusion injury and nephrotoxic nephritis.
  • PD-L1 does not appear to have a protective role in proliferative immune complex glomerulonephritis.

Conclusions:

  • PD-L1's function in renal diseases is complex and context-dependent.
  • Targeting PD-L1, through supplementation or antagonists, shows promise for treating renal diseases.
  • Further research is warranted to fully understand and leverage PD-L1's therapeutic potential in nephrology.
Keywords:
PD-L1acute kidney injuryimmunotherapylupus nephritisrenal disease

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