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Predicting Progression of Untreated Macular Pucker Using Retinal Surface En Face Optical Coherence Tomography.
Daniel Q Li1, Adam K Rudkin2,3, Filiberto Altomare2,3
1Department of Ophthalmology and Visual Sciences, McGill University, Montreal, Québec, Canada.
Summary
Most eyes with premacular membrane (PMM) and good vision remain stable or improve. However, the area of retinal thickening is a novel predictor of vision loss in untreated PMM with macular pucker.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Macular Diseases
Background:
- Premacular membrane (PMM) with macular pucker (MP) affects vision.
- Understanding PMM progression is crucial for patient management.
Purpose of the Study:
- To review visual outcomes in untreated PMM with MP.
- To identify novel predictors of PMM progression.
Main Methods:
- Retrospective analysis of 342 eyes with untreated PMM and MP.
- Spectral-domain optical coherence tomography (SD-OCT) and en face OCT used for imaging.
- Multiple regression analysis to identify predictors of visual acuity change.
Main Results:
- No significant change in visual acuity (VA) or central subfield thickness (CST) over mean 448 days.
- 80% of eyes remained stable or improved; 20% worsened by ≥2 lines.
- Area of retinal thickening (en face OCT) predicted vision loss (OR 1.0606 per mm², p=0.0387).
Conclusions:
- Untreated PMM with good baseline vision often remains stable or improves.
- Area of retinal thickening is a potential novel predictor of vision loss in PMM with MP.
