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Updated: Dec 27, 2025

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
Published on: August 20, 2007
Regulatory T Cells Keep Pancreatic Cancer at Bay
Berk Aykut1, Ruonan Chen1, George Miller2,3
1S. Arthur Localio Laboratory and Department of Surgery, New York University School of Medicine, New York, New York.
Abstract:
Although CD4+ FOXP3+ T regulatory (Treg) cells are well-known mediators of immunologic tolerance, their influences in the tumor microenviroment are incompletely understood. Writing in this issue of Cancer Discovery, Zhang and colleagues demonstrate that in pancreatic cancer, Treg cells promote the differentiation of tumor-restraining myofibroblastic cancer-associated fibroblasts, challenging the existing notion that Treg cells enable tumor progression.See related article by Zhang et al., p. 422.
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