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Surface-Volume Consistent Construction of Longitudinal Atlases for the Early Developing Brain
Sahar Ahmad1, Zhengwang Wu1, Gang Li1
1Department of Radiology and Biomedical Research Imaging Center (BRIC), University of North Carolina, Chapel Hill, USA.
Medical Image Computing and Computer-Assisted Intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
|March 5, 2020
Summary
This study introduces a novel method for creating consistent infant brain atlases, enabling joint surface-volume analysis of brain development from 2 weeks to 12 months.
Area of Science:
- Neuroimaging
- Developmental Neuroscience
- Medical Image Analysis
Background:
- Infant brain atlases are crucial for understanding brain development.
- Current methods often create separate volumetric and cortical atlases, leading to inconsistencies.
- Discrepancies between tissue boundaries and cortical surfaces hinder comprehensive analysis.
Purpose of the Study:
- To develop a method for constructing surface-volume consistent longitudinal infant brain atlases.
- To enable joint analysis of structural changes in the infant brain from 2 weeks to 12 months of age.
- To address the limitations of independent volumetric and cortical atlas construction.
Main Methods:
- Groupwise surface-constrained volumetric registration to create a 12-month atlas.
- Parallel transport of longitudinal displacements to the 12-month atlas space.
- Temporal warping of the 12-month atlas to earlier time points using transported displacements.
Main Results:
- Generated longitudinal infant brain atlases with consistent tissue boundaries and cortical surfaces.
- Demonstrated the feasibility of joint surface-volume analysis within a common atlas space.
- Validated the method for tracking structural brain changes across the first year of life.
Conclusions:
- The proposed method successfully creates surface-volume consistent longitudinal infant brain atlases.
- This approach facilitates integrated analysis of volumetric and cortical brain development.
- The generated atlases provide a valuable tool for studying typical and atypical infant brain maturation.
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