Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantitative PET coronary flow capacity and comprehensive management of chronic CAD: Lessons from the randomized CENTURY trial.

Atherosclerosis·2026
Same author

Measured Coronary Stenosis Pressure-Flow Physiology Or Flawed Angiographic Simulations?

American journal of physiology. Heart and circulatory physiology·2026
Same author

Perceptions of the educational environment during clinical training among Vietnamese medical students: a cross-sectional study.

BMC medical education·2026
Same author

Multiorgan Perfusion by PET: Potential Multiple Pathophysiology Interacting with the Heart to Guide Systemic and Cardiac Management.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

Association between self-reported poor oral health and subjective cognitive decline: a cross-sectional analysis of US survey data.

Alzheimer's research & therapy·2026
Same author

Needs for suicide literacy and training among Vietnamese teachers: Findings from a cross-sectional study.

Asian journal of psychiatry·2026

Related Experiment Video

Updated: Dec 27, 2025

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.7K

Pitfalls in quantitative myocardial PET perfusion II: Arterial input function.

Linh Bui1, Danai Kitkungvan1, Amanda E Roby2

  • 1Department of Medicine, Division of Cardiology and Weatherhead PET Center For Preventing Atherosclerosis, McGovern Medical School and Memorial Hermann Hospital, Houston, TX, USA.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|March 5, 2020
PubMed
Summary

Variable arterial input function in Rubidium-82 (Rb-82) PET can misguide myocardial perfusion severity assessments. Accurate input function is crucial for guiding interventions in 7% of patients.

Keywords:
Quantitative myocardial perfusioncardiac PET

More Related Videos

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

4.1K
Myocardial Infarction and Functional Outcome Assessment in Pigs
12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

28.5K

Related Experiment Videos

Last Updated: Dec 27, 2025

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.7K
High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

4.1K
Myocardial Infarction and Functional Outcome Assessment in Pigs
12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

28.5K

Area of Science:

  • Nuclear Medicine
  • Cardiovascular Imaging
  • Radiopharmacology

Background:

  • Arterial input function (AIF) variability can impact myocardial perfusion quantification.
  • Limited capacity of 3D PET for high-count AIF may affect interventional decisions.
  • Rubidium-82 (Rb-82) is a common PET tracer for myocardial perfusion imaging.

Purpose of the Study:

  • To define the impact of variable AIF on myocardial perfusion severity.
  • To assess the influence of AIF variability on interventional decisions.
  • To evaluate the capacity of 3D PET for high-count AIF quantification.

Main Methods:

  • Utilized GE Discovery-ST 16 slice PET-CT for dynamic acquisitions.
  • Employed a circulating arterial function model with variable Rb-82 doses.
  • Quantified per-pixel rest and stress myocardial perfusion metrics with simulated ±10% AIF changes.

Main Results:

  • Simulated ±10% AIF variability can lead to over- or underestimation of perfusion severity in 7% of cases.
  • This variability may alter interventional decisions for intermediate or border zone perfusion.
  • Phantom tests confirmed 3D PET's capacity for high-activity AIF and high-count perfusion metrics.

Conclusions:

  • Accurate and reproducible AIF is essential for guiding interventions in at least 7% of patients.
  • 3D PET can provide high-activity regional per-pixel perfusion metrics.
  • Quantitative perfusion data should be readily understood by interventionalists to guide procedures.