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Impact of Postoperative Complications on Recurrence in Patients With Stage II/III Gastric Cancer Who Received
Hayato Watanabe1, Tsutomu Hayashi2, Keisuke Komori1
1Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
Background:
This study aimed to investigate the impact of postoperative complications (PCs) in patients with pathological stage (pStage) II or III gastric cancer (GC) who received adjuvant chemotherapy with S-1 after curative surgery.
Patients And Methods:
Altogether, data for 226 patients were examined retrospectively. The relationship between PCs and clinicopathological features and survival were examined.
Results:
Recurrence-free survival was significantly worse in the group with PCs than in the PC-negative group. On multivariate analysis, having PCs of grade 2 or more was an independent risk factor for recurrence (hazard ratio=1.721; 95% confidence intervaI=1.014-2.920; p=0.044). In addition, for each pStage analysis, having PCs of grade 2 or more was a risk factor for recurrence even in patients with pStage II GC.
Conclusion:
PC of grade 2 or more was an independent risk factor for recurrence in patients with pStage II GC who received adjuvant chemotherapy with S-1 after curative gastrectomy. Thus, for patients with PCs, even for those with pStage II GC, more effective adjuvant chemotherapy, such as S-1 plus docetaxel, may be needed.
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