An unusual cause of stridor
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Updated: Dec 27, 2025

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Published on: August 2, 2024
Alison Garde1, Tom N Hilliard1, Michael Saunders2
1Department of Paediatric Respiratory Medicine, Bristol Royal Hospital for Children, Bristol, UK.
Insights
A 12-month-old infant with stridor was diagnosed with a mediastinal mass compressing the airway. Imaging confirmed extrinsic compression of the carina and main bronchi, necessitating intervention.
Area of Science:
- Pediatric Pulmonology
- Thoracic Imaging
- Pediatric Oncology
Background:
- Recurrent stridor in infants can indicate serious underlying pathology.
- Dexamethasone provided transient relief, suggesting an inflammatory or compressive etiology.
Purpose of the Study:
- To investigate the cause of persistent stridor in a 12-month-old infant.
- To characterize the mediastinal mass identified through imaging.
Main Methods:
- Clinical assessment including physical examination and response to corticosteroids.
- Diagnostic imaging including chest radiography, flexible nasendoscopy, microlaryngoscopy, bronchoscopy, and CT thorax.
- Laboratory investigations including complete blood count and C-reactive protein.
Main Results:
- Chest radiograph revealed left lung hyperexpansion and right bronchial narrowing.
- Bronchoscopy identified external airway compression at the carina.
- CT thorax demonstrated a 3cmx2.5cmx1.5cm non-enhancing mediastinal mass extrinsic to the airway, compressing the carina and main-stem bronchi.
Conclusions:
- A mediastinal mass was the cause of the infant's stridor and respiratory distress.
- Multimodality imaging is crucial for diagnosing extrinsic airway compression in pediatric patients.
- Prompt diagnosis and characterization of mediastinal masses are essential for appropriate management.
Abstract:
A 12-month-old infant was referred with a 6-week history of recurrent admissions with worsening stridor. On each previous admission, the stridor responded well, but transiently, to oral dexamethasone. At this presentation, he required high-dependency unit care with high flow oxygen due to marked increased work of breathing.He was born at term, previously well, and up to date with immunisations. There was no significant family history. There were no smokers and two cats at home.He was afebrile with moderate subcostal recession and tracheal tug. On auscultation, breath sounds were normal with transmitted sounds of inspiratory and expiratory stridor. The rest of his examination was normal.He commenced dexamethasone 0.15 μg/kg three times a day, which was weaned as his clinical status improved.Blood tests showed total white cell count 9 x 10ˆ9/L, CRP <1 mg/L, lactate dehydrogenase level and blood film normal. Chest radiograph showed left lung hyperexpansion and apparent right-sided bronchial narrowing (figure 1). Flexible nasendoscopy was unremarkable. Microlaryngoscopy and bronchoscopy showed external airway compression at the level of the carina (figure 2). CT thorax demonstrated a non-enhancing mediastinal mass extrinsic to the airway, approximately 3cmx2.5cmx1.5cm, compressing the carina and main-stem bronchi (figure 3).
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