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Aneurysm III: Interprofessional Care

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...

Aortic Regurgitation III: Medical Management

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...

Aortic Regurgitation I: Introduction

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...

Aortic Regurgitation IV: Nursing Management

Aortic Regurgitation IV: Nursing Management

A nurse managing a patient with aortic regurgitation begins with a comprehensive assessment, including a review of the patient's medical history, family history, and lifestyle factors. During the cardiac examination, the nurse listens for heart sounds and checks for signs of valve abnormalities. The nurse also observes for symptoms such as dyspnea, orthopnea, and paroxysmal nocturnal dyspnea and assesses the patient's endurance and daily activity tolerance.Based on the findings, the nurse...

Aneurysm IV: Nursing Management

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Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...

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Related Experiment Video

Updated: Dec 27, 2025

Surgically Induced Cardiac Volume Overload by Aortic Regurgitation in Mouse

Surgically Induced Cardiac Volume Overload by Aortic Regurgitation in Mouse

Published on: August 30, 2022

Aortic dissection after ramucirumab infusion.

Davide Zenoni¹, Flavio Niccolò Beretta², Vanessa Martinelli¹

¹Hospital Pharmacy Department, ASST Bergamo EST, Alzano Lombardo, Italy.

European Journal of Hospital Pharmacy : Science and Practice

|March 6, 2020

Summary

A rare case of aortic dissection occurred in a patient treated with ramucirumab, a vascular endothelial growth factor pathway inhibitor. This suggests a potential link between this cancer drug and serious cardiovascular events.

Keywords:

adverse effects cardiology chemotherapy gastrointestinal tumours oncology

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Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

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Published on: March 26, 2018

Area of Science:

Oncology
Cardiology
Pharmacology

Background:

A HER2-negative signet-ring cell carcinoma patient received first-line chemotherapy.
Second-line treatment involved paclitaxel and ramucirumab, a vascular endothelial growth factor pathway inhibitor.

Observation:

Shortly after the first ramucirumab administration, the patient developed Stanford type A aortic dissection.
The dissection involved the ascending and descending aorta with a diameter of approximately 6.5 cm.

Findings:

The Naranjo algorithm indicated a 'probable' correlation between ramucirumab and the aortic dissection.
Endothelial dysfunction induced by vascular endothelial growth factor pathway inhibitors is the likely mechanism.

Implications:

This case highlights a potential cardiovascular risk associated with ramucirumab.
Further research is needed to understand and mitigate the risks of vascular endothelial growth factor pathway inhibitors.