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Incidence of Hyperuricemia in Patients with Acute Myocardial Infarction - A Case-Control Study

Kheraj Mal1, Jamila Begum Jabar Ali2, Kiran Fatima3

  • 1Cardiology, National Institute of Cardiovascular Diseases, Sukkur, PAK.

Cureus
|March 6, 2020
PubMed

Insights

Hyperuricemia, or high serum uric acid, is more prevalent in patients experiencing acute myocardial infarction (AMI). This finding suggests screening for high uric acid levels in heart attack patients may be beneficial.

Area of Science:

  • Cardiology
  • Metabolic Disorders

Background:

  • Existing research indicates a link between serum uric acid (sUA) and cardiovascular disease (CVD).
  • Limited local data exists on hyperuricemia prevalence in acute myocardial infarction (AMI) patients within Pakistan.

Purpose of the Study:

  • To determine the prevalence of hyperuricemia in patients diagnosed with AMI.
  • To compare hyperuricemia rates between AMI patients and a control group.

Main Methods:

  • A case-control study was conducted involving 119 AMI patients and 119 controls.
  • Serum uric acid levels were measured within 24 hours of AMI diagnosis.
  • Data was collected from March to November 2019 at a tertiary care hospital in Pakistan.

Main Results:

  • Mean sUA levels were significantly higher in the AMI group (6.17 ± 2.12) compared to the control group (5.51 ± 1.89, p=0.01).
  • Hyperuricemia was more common in AMI patients (47.89%) than in controls (33.6%, p=0.04).

Conclusions:

  • Hyperuricemia is independently associated with acute myocardial infarction.
  • Screening for hyperuricemia should be considered for individuals at high risk for myocardial infarction.

Keywords:
case controlhyperuricemiaincidencemyocardial infarctionpakistan

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