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Urinary bisphenol A concentrations and adiposity measures at age 7 years in a prospective birth cohort

Jianqiu Guo1, Jiming Zhang1, Chunhua Wu1

  • 1School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, No.130 Dong'an Road, Shanghai, 200032, China.

Chemosphere
|March 6, 2020
PubMed

Insights

Prenatal exposure to Bisphenol A (BPA) is linked to increased childhood waist circumference and central obesity risk, particularly in girls. This study highlights potential endocrine disruptor effects on child development.

Area of Science:

  • Environmental Health
  • Pediatric Endocrinology
  • Epidemiology

Background:

  • Early-life exposure to endocrine-disrupting chemicals like Bisphenol A (BPA) is a growing concern for child health.
  • Limited prospective birth cohort data exists on the association between BPA exposure and childhood obesity.
  • Childhood obesity is a significant public health issue with long-term health implications.

Purpose of the Study:

  • To investigate the relationship between maternal and childhood Bisphenol A (BPA) exposure and adiposity measures in children at age 7.
  • To assess associations with body mass index, waist circumference, skinfold thickness, and waist-to-height ratio.
  • To explore potential sex-specific effects of BPA on child adiposity.

Main Methods:

  • A population-based prospective cohort study involving 430 mother-child pairs in rural East China.
  • Quantification of Bisphenol A (BPA) concentrations in maternal and child urine samples at ages 3 and 7 years.
  • Statistical analysis of associations between urinary BPA levels and various child adiposity measures at age 7.

Main Results:

  • Maternal urinary BPA concentration was significantly associated with increased child waist circumference at age 7 (β = 0.508 cm).
  • This association was primarily observed in girls during sex-stratified analyses.
  • Higher tertiles of prenatal BPA exposure were linked to a significantly increased risk of central obesity (p for trend = 0.022).

Conclusions:

  • Prenatal Bisphenol A (BPA) exposure may contribute to increased waist circumference in children.
  • The findings suggest BPA exposure elevates the risk of central obesity, especially in school-age girls.
  • Further research is warranted to understand the mechanisms and long-term consequences of early-life BPA exposure.

Keywords:
Adiposity measuresBisphenol ACentral obesitySchool-age childrenWaist circumference

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