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Related Experiment Videos

Bordetella pertussis does not induce beta-adrenergic blockade.

E Hewlett, A Spiegel, J Wolff

    Infection and Immunity
    |November 1, 1978
    PubMed
    Summary

    Bordetella pertussis causes histamine sensitivity and reduced epinephrine response, but not through beta-adrenergic blockade. Instead, it appears to be due to increased insulin secretion.

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    Area of Science:

    • Immunology
    • Endocrinology
    • Pharmacology

    Background:

    • Bordetella pertussis infection is known to cause histamine sensitivity and alter glucose metabolism.
    • These effects were previously attributed to a generalized beta-adrenergic blockade induced by the bacteria.

    Purpose of the Study:

    • To investigate the mechanism behind Bordetella pertussis-induced changes in histamine sensitivity and epinephrine response.
    • To determine if these effects are mediated by beta-adrenergic blockade.

    Main Methods:

    • Experimental animals were administered Bordetella pertussis.
    • Beta-adrenergic receptor number and affinity were measured using iodohydroxybenzylpindolol binding.
    • Isoproterenol-stimulated adenylate cyclase activity was assessed.
    • Epinephrine-induced hyperglycemia was measured.

    Main Results:

    • Bordetella pertussis administration led to histamine sensitivity and diminished epinephrine-induced hyperglycemia.
    • No changes in beta-adrenergic receptor number or affinity were observed.
    • Isoproterenol-stimulated adenylate cyclase activity remained unchanged.
    • The observed effects were correlated with hyperinsulinemia.

    Conclusions:

    • Bordetella pertussis does not induce a generalized beta-adrenergic blockade.
    • The effects of Bordetella pertussis on histamine sensitivity and glucose metabolism are likely due to bacterial-induced hypersecretion of insulin.

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