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Related Concept Videos

Structures of the Endocrine System00:59

Structures of the Endocrine System

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The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
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Hormonal Regulation01:40

Hormonal Regulation

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Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
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Regulation of Food Intake01:30

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Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
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Regulation of Hormone Secretion01:19

Regulation of Hormone Secretion

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Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral...
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The Endocrine System01:29

The Endocrine System

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The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
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Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

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Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
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Related Experiment Video

Updated: Dec 27, 2025

Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells
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Gut endocrine and neural peptides.

Anne E Bishop1, Julia M Polak1

  • 1Department of Histochemistry, Royal Postgraduate Medical School, London, UK.

Endocrine Pathology
|March 7, 2020
PubMed
Summary

Recent advances in gut hormone research focus on new investigative methods to understand peptide cell function. Studies explore gut endocrine cell development, neural pathways, and the neuroendocrine system

Keywords:
Endocrine CellEndocrine Pathology VolumeNeuroendocrine CellVasoactive Intestinal PeptideVasoactive Intestinal Polypeptide

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Related Experiment Videos

Last Updated: Dec 27, 2025

Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells
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Area of Science:

  • Gastroenterology
  • Endocrinology
  • Neuroscience

Background:

  • The discovery of gut endocrine peptides has slowed, with research shifting to advanced investigative techniques.
  • Understanding the diffuse neuroendocrine system's role in disease is expanding.

Purpose of the Study:

  • To summarize recent advancements in gut hormone research.
  • To highlight the application of new methods in studying gut endocrine cells and peptides.

Main Methods:

  • Application of novel investigative techniques.
  • Analysis of peptide gene expression, control, and rates.
  • Localization and characterization of peptide binding sites.

Main Results:

  • New gut peptides have been identified.
  • Significant progress in understanding gut endocrine cell ontogeny and enteric innervation.
  • Insights into the functional activity of peptide cell systems.

Conclusions:

  • The field of gut hormones is evolving through sophisticated methodologies.
  • Further research is elucidating the complex roles of gut peptides and the neuroendocrine system.