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Comparison of Continuous positive airway pressure versus High flow nasal cannula for Oral feeding Preterm infants

Sandra L Leibel¹, Marina Castro^2,3, Tammy McBride³

¹Division of Neonatology, Department of Pediatrics, Rady Children's Hospital, University of California, San Diego, San Diego, CA, USA.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

|March 7, 2020

Abstract

Objective:

To assess the feasibility of conducting a study comparing nasal continuous positive airway pressure (nCPAP) or heated, humidified, high flow nasal cannula (HHHFNC) on oral feeding in preterm infants.

Study Design:

Randomized controlled pilot study in a level III NICU, of infants' born ≤28°^/7weeks who at 34°^/7weeks post menstrual age (PMA) were dependent on noninvasive ventilation (NIV). Infants were randomized evenly to nCPAP or HHHFNC groups and orally fed on low-flow oxygen. The primary outcomes of enrollment and retention were assessed.

Results:

We enrolled 40 infants and 12 completed the study in the nCPAP group versus 13 in the HHHFNC group. Using our respiratory and feeding protocols, we showed overall enrollment and retention rates (95%CI) at 0.66 (0.54, 0.77) and 0.63 (0.48, 0.78), respectively. Breastfeeding rates were 82% in the nCPAP group and 76% in the HHHFNC group. Infants in the HHHFNC group reached full feeds 7 days earlier than those in the nCPAP group.

Conclusions:

Based on our retention rate, an adequately powered randomized controlled trial can be performed to confirm or refute that HHHFNC is associated with achieving oral feeds earlier.

Trial Registration:

United States National Library of Medicine (www.clinicaltrials.gov) Identifier: NCT02055339. First posted 2/5/2014.

Keywords:

Breastfeeding CPAP HHHFNC oral feeds preterm

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