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Assessment of anti-infective medication adherence in pediatric outpatients

Marion Warembourg1, Nelly Lonca1, Anne Filleron2,3

  • 1Department of Pharmacy, Nimes University Hospital, University of Montpellier, Nimes, France.

European Journal of Pediatrics
|March 7, 2020
PubMed

Insights

Two-thirds of pediatric patients were non-adherent to anti-infective drugs after hospital discharge. Poor adherence to antibiotics in children may stem from a lack of parental knowledge, highlighting the need for better therapeutic education.

Area of Science:

  • Pediatric Infectious Diseases
  • Pharmacology
  • Public Health

Background:

  • Non-adherence to anti-infective drugs contributes to antibiotic resistance.
  • Limited research exists on pediatric medication adherence post-hospital discharge for acute infections.

Purpose of the Study:

  • To evaluate pediatric adherence to anti-infective drugs upon hospital discharge.
  • To identify risk factors associated with non-adherence in children.

Main Methods:

  • Pilot study involving pediatric patients discharged with oral anti-infectives.
  • Adherence assessed via parental interviews covering medication use and knowledge.
  • Data collected over a 3-month period.

Main Results:

  • Overall adherence to anti-infectives was 34.9% among 63 pediatric patients.
  • Amoxicillin and amoxicillin/clavulanic acid were most prescribed.
  • Lack of parental knowledge correlated with non-adherence.

Conclusions:

  • A significant majority of pediatric outpatients were non-adherent to anti-infectives for acute infections.
  • Misunderstanding of treatment regimens is a potential risk factor for non-adherence.
  • Therapeutic education and pharmaceutical counseling at discharge could enhance adherence.

Keywords:
Anti-infective agentsInfectious diseasesMedication adherenceOutpatient monitoringPediatric

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