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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Self-motion perception in Parkinson's disease.

Orly Halperin¹, Simon Israeli-Korn^2,3, Sol Yakubovich¹

¹Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, Israel.

The European Journal of Neuroscience

|March 7, 2020

Summary

Parkinson's disease impairs self-motion perception by affecting visual, vestibular, and somatosensory systems. This dysfunction impacts balance and gait, suggesting new therapeutic targets for motor symptoms.

Keywords:

action-perception loop multisensory integration optic flow somatosensory vestibular

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Area of Science:

Neuroscience
Movement Disorders
Sensory Integration

Background:

Parkinson's disease (PD) presents with motor and non-motor symptoms, including perceptual deficits.
Motor and perceptual functions are interconnected via an action-perception loop.
Self-motion perception, crucial for balance and mobility, relies on integrating visual, vestibular, and somatosensory inputs.

Purpose of the Study:

To review perceptual deficits impacting self-motion perception in Parkinson's disease.
To explore the link between impaired sensory processing and motor dysfunction in PD.
To highlight the need for further research into self-motion perception and multisensory integration in PD.

Main Methods:

Review of existing literature on perceptual and motor functions in Parkinson's disease.
Analysis of how visual, vestibular, and somatosensory deficits affect self-motion perception.
Examination of evidence for impaired multisensory integration in PD.

Main Results:

Dysfunction in central brain mechanisms impairs visual, vestibular, and somatosensory processing in PD.
Self-motion perception, particularly visual and multisensory integration, is demonstrably impaired in PD.
These impairments can negatively affect motor control, gait, and balance.

Conclusions:

Impaired self-motion perception is a significant, understudied aspect of Parkinson's disease.
Understanding these deficits may aid in PD diagnosis, subtyping, and developing novel therapies.
Future research should focus on sensory augmentation or retraining for gait and balance issues in PD.