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Probiotic Studies in Neonatal Mice Using Gavage
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[ANALYSIS OF THE USE OF ANTIBIOTIC THERAPY IN PREMATURE INFANTS, TAKING INTO ACCOUNT THE CHARACTERISTICS OF THE

N Kobeshavidze1, D Chikviladze2, Kh Gachechiladze2

  • 11LTD "Imedis Clinica", Tbilisi, Georgia.

Georgian Medical News
|March 7, 2020
PubMed

Insights

This study analyzed microbial resistance in premature infants, finding gram-positive bacteria predominated. Antibiotic use varied significantly, impacting microbial sensitivity during the neonatal period.

Area of Science:

  • Neonatal microbiology
  • Antibiotic resistance
  • Microbial ecology in infants

Background:

  • Premature infants face unique microbial challenges.
  • Microbial colonization of respiratory, urinary, and colon tracts is critical.
  • Understanding early-life microbial dynamics is essential for health outcomes.

Purpose of the Study:

  • To determine the antibiotic sensitivity/resistance patterns of microbial strains in premature infants.
  • To assess the influence of hospitalization and antibiotic therapy duration on microbial resistance.
  • To characterize microbial flora in key neonatal biotopes.

Main Methods:

  • Isolation and identification of 677 microbial strains from respiratory, urinary, and colon biotopes.
  • Antibiotic sensitivity/resistance testing using disc diffusion and dilution methods.
  • Analysis of antibiotic therapy regimens and duration in hospitalized newborns.

Main Results:

  • Gram-positive flora (386 strains) predominated over gram-negative flora (291 strains).
  • Antibiotic therapy duration ranged from 19 to 22 days, with 4-17 different regimens used.
  • Carbapenems, Glycopeptide, third-generation Cephalosporins, and Aminoglycosides were frequently administered.

Conclusions:

  • Neonatal microbial colonization patterns show a predominance of gram-positive bacteria.
  • Prolonged and varied antibiotic use in premature infants influences microbial resistance.
  • Further research is needed to optimize antibiotic stewardship in neonatal intensive care units.

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