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[Autoimmunity in thyroid disease secondary to amiodarone: heredofamilial aspects]
R Olguín1, L Nungaray, P A Reyes
1Departamento de Endocrinología e Inmunología, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F.
Archivos Del Instituto De Cardiologia De Mexico
|May 1, 1988
Summary
Spontaneous autoimmune thyroid disease (SATD) has a genetic link. Patients with a family history of thyroid issues face a 7.6 times higher risk of developing amiodarone-induced thyroid dysfunction.
Area of Science:
- Endocrinology
- Genetics
- Immunology
Context:
- Spontaneous autoimmune thyroid disease (SATD) exhibits familial aggregation.
- Amiodarone treatment can precipitate thyroid dysfunction in susceptible individuals.
- Previous research indicated a genetic predisposition in amiodarone-induced thyroid dysfunction.
Purpose:
- To identify risk factors for amiodarone-related thyroid dysfunction.
- To investigate the role of autoantibodies and family history in amiodarone-treated patients.
- To compare patients with amiodarone-induced thyroid dysfunction, SATD, and healthy controls.
Summary:
- Organ-specific antibodies (anti-thyroglobulin, gastric mucosa, myocardium) were more frequent in patient groups than controls.
- Antithyroglobulin antibody frequency did not differ between amiodarone patients with or without thyroid dysfunction.
- A family history of thyroid disease was significantly more common in patients with SATD and amiodarone-related dysthyroidism.
Impact:
- Clinical thyroid disease development is linked to individual genetic predisposition.
- Patients with a positive family history have a substantially increased risk (7.6-fold) of amiodarone-induced clinical thyroid disease.
- Findings aid in stratifying risk and understanding the genetic underpinnings of amiodarone-induced thyroid dysfunction.