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Age-wise trends in alkaline phosphatase activity in 167,625 Chinese children aged 0-18 years

Kui-Lin Lü1, Shuang-Shuang Xie2, En Liu3

  • 1Department of Pediatrics, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, PR China.

Clinical Biochemistry
|March 7, 2020
PubMed

Insights

Alkaline phosphatase (ALP) levels in children aged 0-18 show distinct age-related patterns, peaking earlier in girls and differing between Chinese and German populations. These findings establish crucial reference values for pediatric clinical use.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Clinical Chemistry

Background:

  • Alkaline phosphatase (ALP) is a key diagnostic biomarker in adults.
  • Pediatric ALP activity fluctuates significantly with age and physiological changes, limiting its diagnostic utility without age-specific reference values.

Purpose of the Study:

  • To investigate the age-specific dynamics of alkaline phosphatase (ALP) activity in children aged 0-18 years.
  • To establish reliable reference values for pediatric ALP activity.
  • To compare ALP activity patterns between Chinese and German children.

Main Methods:

  • Analysis of 167,625 pediatric samples (0-18 years).
  • ALP activity measured using the 4-nitrophenyl-1-phosphate disodium salt (4-NPP)-2-amino-2-methyl-1-propanol (AMP) method.
  • Percentile curves generated using MATLAB and fitted with the LMS method, excluding patients with conditions affecting ALP.

Main Results:

  • ALP activity peaks in boys aged 12-13 years and in girls aged 10-11 years.
  • Activity declines in both sexes through adolescence.
  • The peak ALP activity observed in Chinese children occurred earlier than in German children.

Conclusions:

  • The study elucidates the age-dependent dynamics of ALP activity in Chinese children (0-18 years).
  • Significant differences in ALP activity timing were noted between Chinese and German children.
  • Provides essential reference data for pediatric clinical interpretation of ALP levels.
Abstract

Keywords:
Age distributionAlkaline phosphatasePediatricPercentileReference intervals

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