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Development and Characterization of a Benchtop Corneal Puncture Injury Model.

Eric J Snider1, Lauren E Cornell2, Jorge M Acevedo2

  • 1Sensory Trauma Research Department, United States Army Institute of Surgical Research, Fort Sam Houston, TX, 78234, USA. Eric.J.Snider3.ctr@mail.mil.

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|March 8, 2020
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Summary

A new benchtop model simulates battlefield corneal puncture injuries, aiding therapeutic development for soldiers. This high-speed solenoid device creates realistic injuries, improving treatment assessment for severe eye trauma.

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Trauma Research

Background:

  • Military operations involving explosive weaponry have increased the incidence of severe corneal puncture injuries.
  • These injuries often lead to poor visual outcomes, including blindness, due to varied injury characteristics.
  • Current injury models inadequately replicate battlefield conditions, hindering therapeutic development.

Purpose of the Study:

  • To develop a novel benchtop model for simulating military-relevant corneal puncture injuries.
  • To create a standardized platform for assessing potential therapeutics for severe eye trauma.
  • To improve the characterization of corneal injuries sustained in combat settings.

Main Methods:

  • Utilized a high-speed solenoid device with enucleated eyes to create corneal puncture injuries.
  • Established system baselines and ocular performance metrics for model standardization.
  • Evaluated the model using injury objects up to 4.2 mm in diameter, generating high intraocular pressures.

Main Results:

  • The benchtop model successfully generated military-relevant corneal puncture injuries.
  • System standardization ensured consistent results and accounted for ocular tissue variability.
  • The model achieved intraocular pressure levels exceeding 1500 mmHg.

Conclusions:

  • The developed benchtop model provides a realistic platform for studying corneal puncture injuries from military settings.
  • This model facilitates better characterization of complex eye injuries and evaluation of novel therapeutics.
  • It represents a significant advancement for improving visual outcomes in soldiers with combat-related eye trauma.