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Related Experiment Videos

Characterization of morphine's excitatory effects.

D E Jorenby1, R E Keesey, T B Baker

  • 1Department of Psychology, University of Wisconsin, Madison 53706.

Behavioral Neuroscience
|December 1, 1988
PubMed
Summary

Morphine

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Physiology

Background:

  • Excitatory effects of opiates are crucial for understanding compulsive drug use.
  • The precise nature and time course of these excitatory effects remain poorly understood.

Purpose of the Study:

  • To characterize the excitatory effects of morphine.
  • To investigate the influence of environmental temperature on these effects.

Main Methods:

  • Administered morphine at 5 mg/kg and 20 mg/kg doses.
  • Conducted experiments in both warm and cold environments.
  • Simultaneously assessed core temperature, locomotor activity, and oxygen consumption.

Main Results:

  • Morphine administration altered core temperature, locomotor activity, and oxygen consumption.
  • Environmental temperature modulated these morphine-induced changes.
  • Evidence suggests a dual-receptor mechanism for morphine's thermic effects.

Conclusions:

  • A two-receptor model is proposed for morphine's thermic effects.
  • A high-affinity receptor activates thermogenic systems.
  • A low-affinity receptor mediates a poikilothermic response.

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