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Updated: Dec 26, 2025
Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity AIDN: A Translational Neuroscience Approach
Published on: June 11, 2017
Standards for preclinical research and publications in developmental anaesthetic neurotoxicity: expert opinion
Gregory A Chinn1, Matthew L Pearn2, Laszlo Vutskits3
1Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
Abstract:
In March 2019, SmartTots, a public-private partnership between the US Food and Drug Administration and the International Anesthesia Research Society, hosted a meeting attended by research experts, anaesthesia journal editors, and government agency representatives to discuss the continued need for rigorous preclinical research and the importance of establishing reporting standards for the field of anaesthetic perinatal neurotoxicity. This group affirmed the importance of preclinical research in the field, and welcomed novel and mechanistic approaches to answer some of the field's largest questions. The attendees concluded that summarising the benefits and disadvantages of specific model systems, and providing guidance for reporting results, would be helpful for designing new experiments and interpreting results across laboratories. This expert opinion report is a summary of these discussions, and includes a focused review of current animal models and reporting standards for the field of perinatal anaesthetic neurotoxicity. This will serve as a practical guide and road map for novel and rigorous experimental work.
Insights
Experts emphasize rigorous preclinical research and standardized reporting for anesthetic perinatal neurotoxicity. This guide reviews animal models and reporting standards to improve experimental design and results interpretation.
Area of Science:
- Neuroscience
- Toxicology
- Anesthesiology
Background:
- Anesthetic perinatal neurotoxicity is a growing concern.
- Current preclinical research lacks standardized reporting, hindering interpretation.
- Novel mechanistic approaches are needed to address knowledge gaps.
Purpose of the Study:
- To summarize expert discussions on preclinical research needs in anesthetic perinatal neurotoxicity.
- To review current animal models and reporting standards.
- To provide a practical guide for future research in this field.
Main Methods:
- Convened a meeting of experts, journal editors, and government representatives.
- Conducted a focused review of existing animal models.
- Analyzed current reporting standards for perinatal neurotoxicity studies.
Main Results:
- Affirmed the critical need for rigorous preclinical research.
- Highlighted the importance of novel and mechanistic research approaches.
- Identified the need for summarizing model system pros and cons and providing reporting guidance.
Conclusions:
- Standardized reporting and clear guidance on model systems are essential.
- This report serves as a roadmap for designing and interpreting experiments.
- Future research should focus on rigorous, standardized approaches to understand anesthetic neurotoxicity.
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