![Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F3777.jpg&w=3840&q=50)
FDG-PET/CT in Inflammatory Bowel Disease: Is There a Future?
Jacob Broder Brodersen1, Søren Hess2
1Department of Gastroenterology, Hospital of Southwest Jutland, Finsensgade 35, Esbjerg Dk-6700, Denmark.
Fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) shows promise for inflammatory bowel disease, particularly in assessing treatment response and strictures. Further research is needed to clarify its role in diagnosis and management.
Area of Science:
- Nuclear Medicine
- Gastroenterology
- Medical Imaging
Background:
- Fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) is being explored for inflammatory bowel disease (IBD).
- Existing literature suggests good sensitivity and specificity for FDG-PET/CT in various IBD contexts.
Purpose of the Study:
- To evaluate the current and potential roles of FDG-PET/CT in the management of inflammatory bowel disease.
- To identify key areas where FDG-PET/CT demonstrates clinical utility and areas requiring further investigation.
Main Methods:
- Systematic review of existing literature on FDG-PET/CT applications in IBD.
- Analysis of diagnostic performance metrics (sensitivity, specificity) in different clinical scenarios.
Main Results:
- FDG-PET/CT shows significant potential for assessing early treatment response in IBD.
- Characterization of strictures in IBD is a promising application.
- Current use in initial diagnosis should be limited to equivocal cases.
- Imaging challenges due to bowel motility and physiological activity exist.
Conclusions:
- FDG-PET/CT is valuable for evaluating treatment response and strictures in IBD.
- Its role in initial diagnosis requires further validation.
- Technical challenges in imaging the gastrointestinal tract need to be addressed.
- More research is essential to establish definitive conclusions on FDG-PET/CT's role in IBD.
More Related Videos
10:28Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
07:05Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
Published on: December 15, 2017
Related Concept Videos
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:25Imaging Studies II: Positron Emission Tomography and Scintigraphy
Fundamental Principles of PET
01:26Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
01:29Positron Emission Tomography
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...