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Percutaneous coronary intervention in aorto-ostial coronary chronic total occlusion: outcomes and technical
Soledad Ojeda1, Aurora Luque1, Manuel Pan1
1Departamento de Cardiología, Hospital Reina Sofía, Universidad de Córdoba, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain.
Insights
Percutaneous coronary intervention (PCI) for aorto-ostial chronic total coronary occlusion (CTO) is challenging. Successful PCI is achievable with experienced operators, particularly when interventional collaterals enable a retrograde approach.
Area of Science:
- Cardiology
- Interventional Cardiology
- Vascular Medicine
Background:
- Aorto-ostial chronic total coronary occlusion (CTO) presents unique challenges for percutaneous coronary intervention (PCI).
- Optimizing PCI strategies for this specific lesion subset is crucial for improving patient outcomes.
Purpose of the Study:
- To analyze the technical aspects and outcomes of PCI in patients with aorto-ostial CTO.
- To identify factors influencing procedural success and complications in this challenging group.
Main Methods:
- A multicenter registry included 103 patients undergoing aorto-ostial CTO PCI between February 2013 and December 2018.
- Technical and procedural success rates, crossing techniques, and complications were analyzed.
Main Results:
- Technical and procedural success rates were 76.7% and 75.7%, respectively.
- The retrograde approach was the most successful crossing technique (62.0%), particularly with interventional collaterals.
- Absence of interventional collaterals was the only independent predictor of technical failure (OR, 12.38).
- Complications included coronary perforation (3.9%) and stroke (1.9%).
- At a median follow-up of 31 months, cardiovascular death occurred in 2.9% and repeat revascularization in 12.6%.
Conclusions:
- Aorto-ostial CTOs are a difficult subset for PCI, but acceptable success rates and favorable outcomes are achievable.
- Experienced operators and the utilization of the retrograde approach, facilitated by interventional collaterals, are key to successful PCI in this population.
Introduction And Objectives:
Percutaneous coronary intervention (PCI) for aorto-ostial chronic total coronary occlusion (CTO) can be a particularly challenging lesion subset. The aim of this study was to analyze the technical aspects and outcomes of aorto-ostial CTO PCI in a multicenter registry.
Methods:
Patients undergoing aorto-ostial CTO PCI at 4 centers between February 2013 and December 2018 were included. Success rates, as well as procedural aspects and outcomes, were analyzed.
Results:
A total of 103 patients were included. Mean age was 64±10 years and the mean J-CTO score was 3.1±1.1. Thirty-one lesions (30.4%) were flush ostial CTOs. Technical and procedural success were achieved in 79 (76.7%) and 78 (75.7%) of the patients, respectively. The retrograde approach was the most frequent successful crossing technique (n=49; 62.0%), especially in flush vs nonflush aorto-ostial CTOs (82.6% vs 53.5%; P=.02). The only variable independently associated with technical failure was the absence of interventional collaterals (OR, 12.38; 95%CI, 4.02-38.15; P <.001). Coronary perforation occurred in 4 patients (3.9%) requiring covered stent implantation (without subsequent cardiac tamponade) and 2 patients (1.9%) had a stroke (one of which was a transient ischemic attack). During a median follow-up of 31 months, 3 (2.9%) patients died from cardiovascular causes and 13 (12.6%) required repeat target vessel revascularization.
Conclusions:
Aorto-ostial occlusions represent a challenging subset for PCI. However, an acceptable success rate with favorable outcomes during follow-up can be achieved by experienced operators. The presence of interventional collaterals allowing the use of the retrograde approach is key for achieving procedural success.
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