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Characterization of Motor Activity of Spermatozoa in Adult Progeny of Female Rats with Experimental Type 1 Diabetes
1Department of Histology, Embryology, and Cytology, South-Ural State Medical University, Ministry of Health of the Russian Federation, Chelyabinsk, Russia.
Abstract:
We studied the influence of maternal experimental streptozotocin-induced type 1 diabetes mellitus on motility of spermatozoa in adult progeny. A decrease in the summary count of spermatozoa and changes in their subpopulation composition were revealed. Specifically, the count of nonfertile spermatozoa (immotile and jerking cells) increased, while fertile fraction (progressively motile and low motile cells) decreased. These shifts were responsible for lower index of spermatozoon motility (proportion of fertile to infertile sums of spermatozoa) in the progeny of females with experimental type 1 diabetes mellitus. These results persuasively demonstrated the negative impact of maternal diabetes mellitus on the motor activity of the male germ cells in the progeny under experimental conditions.
