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Updated: Dec 26, 2025

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
Personalized Approach in the Work-up and Management of Gastroesophageal Reflux Disease
Rena Yadlapati1, John E Pandolfino2
1Division of Gastroenterology, University of California San Diego, 9500 Gilman Drive MC 0956, La Jolla, CA 92093, USA.
Abstract:
Patients with gastroesophageal reflux disease (GERD) present with heterogeneous symptoms, response to treatment, and physiologic profiles, requiring distinct and personalized management. This article provides a stepwise framework to phenotype GERD beginning with (1) characterization of symptom profile and response to acid suppression; (2) endoscopic evaluation of mucosal and anatomic integrity; (3) ambulatory reflux monitoring to characterize reflux burden and sensitivity; and (4) esophageal physiologic testing to assess gastroesophageal reflux mechanism and effectors of reflux clearance, and evaluate for alternate causes.
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