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Related Experiment Video

Updated: Dec 26, 2025

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

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Quantitative MRCP Imaging: Accuracy, Repeatability, Reproducibility, and Cohort-Derived Normative Ranges.

Marc H Goldfinger¹, Gerard R Ridgway¹, Carlos Ferreira¹

¹Perspectum Ltd, Oxford, UK.

Journal of Magnetic Resonance Imaging : JMRI

|March 10, 2020

Summary

A new quantitative Magnetic Resonance Cholangiopancreatography (MRCP) tool offers accurate, repeatable, and reproducible measurements for objectively assessing biliary disease. This advancement moves beyond subjective assessments in noninvasive imaging.

Keywords:

3D-printed phantom biliary disease magnetic resonance cholangiopancreatography (MRCP)quantitative metrics repeatability reproducibility

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Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

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Published on: September 8, 2021

Area of Science:

Medical Imaging
Quantitative MRI
Biliary System Imaging

Background:

Magnetic Resonance Cholangiopancreatography (MRCP) is crucial for noninvasive biliary disease imaging.
Current MRCP assessment is subjective, necessitating objective biomarkers for improved diagnosis.

Purpose of the Study:

To evaluate the accuracy, repeatability, and reproducibility of a novel quantitative MRCP tool.
To establish normative ranges for duct measurements and biliary tree metrics in healthy individuals.

Main Methods:

Utilized heavily T2-weighted 3D multishot fast/turbo spin echo sequences at 1.5T and 3T.
Assessed phantoms and in vivo data across multiple scanners and field strengths.
Employed Bland-Altman analysis and repeatability coefficient for statistical evaluation.

Main Results:

Quantitative MRCP demonstrated accuracy close to scanning resolution (95% LoA: -1.1 to 1.0 mm).
Excellent phantom repeatability (LoA: -0.4 to 0.4 mm) and good cross-scanner reproducibility were observed.
Significant differences in metrics like CBD diameter and biliary tree volume were found between patients and healthy volunteers.

Conclusions:

Quantitative MRCP provides objective, accurate, and reproducible measurements for assessing cholangiopathic changes.
This tool has the potential to enhance the diagnostic capabilities of MRCP for biliary diseases.