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Updated: Dec 26, 2025

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Eye Symptoms in a Patient With Prostate Cancer.

Kalevi Kairemo1, Aki Kangasmäki, Timo Joensuu2

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Summary
This summary is machine-generated.

Fluorine-18 prostate-specific membrane antigen (PSMA) PET/CT identified extensive metastases in a prostate cancer patient. Subsequent Lutetium-18 PSMA-617 therapy successfully treated an unexpected lesion near the eye.

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiopharmaceuticals

Background:

  • Castration-resistant prostate cancer (CRPC) presents significant treatment challenges.
  • Prostate-specific membrane antigen (PSMA) targeted therapies offer a novel treatment modality.
  • Advanced imaging is crucial for precise staging and treatment monitoring.

Observation:

  • Extensive PSMA-positive skeletal metastases were identified using F-PSMA PET/CT in a CRPC patient.
  • An unexpected, PSMA-avid lesion adjacent to the left eye was detected on delayed SPECT/CT post-F-PSMA imaging.
  • The patient experienced resolution of eye pain following treatment.

Findings:

  • Lutetium-18 PSMA-617 (Lu-PSMA-617) therapy was administered for widespread skeletal metastases.
  • The previously identified orbital lesion showed decreased activity on SPECT/CT after the first Lu-PSMA-617 cycle.
  • The orbital lesion was no longer visible on SPECT/CT after the second treatment cycle, correlating with symptom resolution.

Implications:

  • PSMA-targeted therapies demonstrate efficacy in treating advanced prostate cancer.
  • Delayed imaging may reveal unexpected metastatic sites or treatment responses.
  • Lu-PSMA-617 therapy can effectively target and treat previously undetected metastatic lesions, improving patient outcomes.