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Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Related Experiment Video

Updated: Dec 26, 2025

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
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ICFSR Task Force Perspective on Biomarkers for Sarcopenia and Frailty.

L Rodriguez-Mañas1, I Araujo de Carvalho, S Bhasin

  • 1L. Rodriguez Mañas, Hospital Universitario de Getafe, Spain, leocadio.rodriguez@salud.madrid.org.

The Journal of Frailty & Aging
|March 10, 2020
PubMed
Summary
This summary is machine-generated.

Researchers are developing new biomarkers for aging conditions like frailty and sarcopenia. The D3Cr dilution method shows promise for measuring muscle mass, aiding in better diagnostics and treatments.

Keywords:
Frailtybiomarkersconsensussarcopenia

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Area of Science:

  • Gerontology
  • Biochemistry
  • Biomarker Discovery

Background:

  • Frailty and sarcopenia are significant aging conditions requiring advanced diagnostic tools and treatments.
  • Biomarker development is crucial for understanding and managing these age-related declines.
  • The International Conference on Frailty and Sarcopenia Research (ICFSR) convened experts to address this need.

Purpose of the Study:

  • To review the current landscape of biomarker development for frailty and sarcopenia.
  • To identify promising biomarkers and methodologies for assessing these conditions.
  • To discuss challenges and international efforts in biomarker research.

Main Methods:

  • Discussion and consensus among an international task force of academic and industry scientists.
  • Evaluation of the D3Cr dilution method for assessing muscle mass.
  • Identification of proposed frailty biomarkers including inflammation and endocrine markers.

Main Results:

  • The D3Cr dilution method was proposed as a more accurate measure of functional muscle mass compared to DXA.
  • Proposed frailty biomarkers encompass inflammation, hypothalamic-pituitary-adrenal (HPA) axis function, glucose-insulin dynamics, and endocrine dysregulation.
  • The complex, multisystem nature of frailty was acknowledged.

Conclusions:

  • Advancing biomarker development is essential for improving the diagnosis and treatment of frailty and sarcopenia.
  • Overcoming regulatory pathway clarity is key to accelerating biomarker progress.
  • International collaborative efforts are underway to develop and validate these critical biomarkers.