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Retinal cavitations in macular telangiectasia type 2 (MacTel): longitudinal structure-function correlations.

Cindy X Cai1, John Choong1, Sina Farsiu1

  • 1Department of Ophthalmology, Duke Medicine, Durham, North Carolina, USA.

The British Journal of Ophthalmology
|March 11, 2020
PubMed
Summary

Retinal cavitation volume in Macular Telangiectasia type 2 (MacTel) can be measured using OCT. Increased cavitation correlates with worse visual acuity, suggesting it may be a biomarker for MacTel progression.

Keywords:
MaculaRetina

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Diseases

Background:

  • Macular Telangiectasia type 2 (MacTel) is a degenerative retinal disease.
  • Quantifying retinal cavitation and its progression is crucial for understanding MacTel.
  • Current methods for assessing MacTel progression need refinement.

Purpose of the Study:

  • To quantify retinal cavitation volume over time in MacTel patients.
  • To correlate changes in cavitation volume with visual acuity and ellipsoid zone loss.
  • To evaluate the potential of retinal cavitation as a biomarker for MacTel progression.

Main Methods:

  • Analysis of Optical Coherence Tomography (OCT) macula volume scans from MacTel patients in a clinical trial.
  • Segmentation of retinal cavitations by two independent readers.
  • Comparison of cavitation volume with best-corrected visual acuity (BCVA) and ellipsoid zone loss.

Main Results:

  • Excellent inter-reader reliability for cavitation volume quantification (>0.99).
  • Average cavitation volume increased over 2 years (+0.0039 mm³/year).
  • Increased cavitation volume was associated with worse BCVA and negatively correlated with it (r=-0.37).

Conclusions:

  • Retinal cavitations in MacTel can be reliably quantified using OCT.
  • Cavitation volume is a potential OCT-based biomarker for MacTel progression.
  • Cavitation volume is negatively correlated with visual function in MacTel.