Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

146
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
146
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

142
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
142

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expansion, functional diversification, and gene fusion events in the Ato protein family.

iScience·2026
Same author

Estimating Work-Related Indirect Costs in Allergic Rhinitis and Asthma Using a Daily Combined Symptom-Medication Score: A MASK-air Study in Collaboration With the EAACI Methodology Committee.

The journal of allergy and clinical immunology. In practice·2026
Same author

Comparison of Allergic Rhinitis Treatments on Utilities and Quality of Life: A MASK-air Study.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

Treatment Dose Increase Versus Co-Medication in Allergic Rhinitis: Systematic Review With Dose-Response Network Meta-Analysis.

Allergy·2026
Same author

Availability and Costs of Allergic Rhinitis Treatments Across the World: A Survey of ARIA Experts.

Allergy·2026
Same author

Allergic Rhinitis and Its Impact on Asthma (ARIA)-EAACI Guidelines-2024-2025 Revision: Part II-Guidelines on Oral and Ocular Treatments.

Allergy·2026

Related Experiment Video

Updated: Dec 26, 2025

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro
10:01

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro

Published on: April 8, 2020

6.3K

Elastins-Based Antimicrobial Particles for Delivery of Bioactive Compounds.

Raul Machado1,2, André da Costa3,4, Ana Margarida Pereira3,4

  • 1CBMA (Centre of Molecular and Environmental Biology), Department of Biology, University of Minho, Braga, Portugal. machado@bio.uminho.pt.

Methods in Molecular Biology (Clifton, N.J.)
|March 11, 2020
PubMed
Summary

Researchers developed novel, non-toxic particles with built-in antimicrobial properties for drug delivery. These self-assembling particles can encapsulate bioactive compounds, offering a promising platform for advanced therapeutic applications.

Keywords:
Antimicrobial peptideElastin-like recombinamerEncapsulationParticlesSelf-assembly

More Related Videos

Author Spotlight: An Antimicrobial Fabric Using Nano-Herbal Encapsulation of Essential Oils
07:47

Author Spotlight: An Antimicrobial Fabric Using Nano-Herbal Encapsulation of Essential Oils

Published on: April 7, 2023

8.8K
Production of Elastin-like Protein Hydrogels for Encapsulation and Immunostaining of Cells in 3D
11:46

Production of Elastin-like Protein Hydrogels for Encapsulation and Immunostaining of Cells in 3D

Published on: May 19, 2018

13.0K

Related Experiment Videos

Last Updated: Dec 26, 2025

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro
10:01

Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro

Published on: April 8, 2020

6.3K
Author Spotlight: An Antimicrobial Fabric Using Nano-Herbal Encapsulation of Essential Oils
07:47

Author Spotlight: An Antimicrobial Fabric Using Nano-Herbal Encapsulation of Essential Oils

Published on: April 7, 2023

8.8K
Production of Elastin-like Protein Hydrogels for Encapsulation and Immunostaining of Cells in 3D
11:46

Production of Elastin-like Protein Hydrogels for Encapsulation and Immunostaining of Cells in 3D

Published on: May 19, 2018

13.0K

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Antimicrobial Research

Background:

  • Developing multifunctional drug delivery systems requires balancing efficacy with biocompatibility and high encapsulation.
  • Existing systems often struggle to combine antimicrobial properties with efficient drug loading.
  • There is a need for novel materials that are safe, effective, and versatile for complex therapeutic challenges.

Purpose of the Study:

  • To describe the preparation of novel, non-cytotoxic particles with intrinsic antimicrobial activity.
  • To demonstrate the ability of these particles to encapsulate bioactive compounds for drug delivery.
  • To provide methods for evaluating antimicrobial activity, cytotoxicity, and encapsulation efficiency.

Main Methods:

  • Utilized a recombinantly produced elastin-like recombinamer functionalized with an antimicrobial peptide.
  • Exploited the thermoresponsive properties of the elastin-like portion for spontaneous self-assembly under mild conditions.
  • Established protocols for assessing antimicrobial efficacy, cytotoxicity, and bioactive compound entrapment.

Main Results:

  • Successfully prepared non-cytotoxic particles with inherent antimicrobial properties.
  • Demonstrated spontaneous self-assembly of the functionalized elastin-like recombinamer under mild, physiological conditions.
  • Laid the groundwork for encapsulating various bioactive compounds within these antimicrobial particles.

Conclusions:

  • The developed self-assembling particles offer a promising, biocompatible platform for multifunctional drug delivery.
  • The intrinsic antimicrobial activity combined with encapsulation capabilities addresses key challenges in advanced therapeutics.
  • The provided methods facilitate the reproducible preparation and evaluation of these novel drug delivery vehicles.