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Updated: Dec 26, 2025

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
Published on: July 6, 2016
Visibly Emitting Thiazolyl-Uridine Analogues as Promising Fluorescent Probes
Jinsi Li1, Xuerong Fang1, Xin Ming1
1Department of Pharmacy, Chengdu Medical College, No. 783 Xindu Avenue, Chengdu, Sichuan 610500, P. R. China.
Abstract:
Microenvironment-sensitive fluorescent (ESF) nucleosides are powerful tools for nucleic acid research. The new 5-substituted uridine analogues are synthesized, which comprise a 4H-cyclopenta[d]thiazole ring obtained by the Hantzsch synthesis reaction of 5-thioamide-uridine with aromatic α-bromocarbonyl compounds. The emission maximum of new compounds is in the visible region. They exhibit strong solvent- and pH-dependent fluorescent properties, indicating their promising ability to be fluorescent probes.
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