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Ruminative Tendency Relates to Ventral Striatum Functionality: Evidence From Task and Resting-State fMRI.

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  • 1Sagol Brain Institute Tel Aviv, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

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|March 11, 2020
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Summary
This summary is machine-generated.

Trait rumination is linked to altered brain activity in the ventral striatum/nucleus accumbens (VS/NAcc). Higher rumination scores correlate with VS/NAcc reward response and connectivity during ruminative states.

Keywords:
depressionnucleus accumbensrewardruminationventral striatum

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Ruminative responding, characterized by repetitive negative thinking, impedes adaptive coping strategies.
  • The ventral striatum/nucleus accumbens (VS/NAcc) mediates reward-directed behaviors crucial for alleviating depressive states.
  • Previous research has not investigated the relationship between trait rumination and VS/NAcc functionality.

Purpose of the Study:

  • To investigate the association between trait rumination and VS/NAcc function.
  • To determine if rumination moderates VS/NAcc activity in response to reward.
  • To examine VS/NAcc functionality during a ruminative state.

Main Methods:

  • Trait rumination was assessed using the Rumination Response Scale (RRS).
  • fMRI was employed in 80 participants (community and major depressive disorder patients) to measure VS/NAcc function during reward anticipation and resting-state.
  • Statistical analyses controlled for depressive symptom severity.

Main Results:

  • RRS scores showed a positive correlation with VS/NAcc response to reward.
  • Higher RRS scores were associated with increased resting-state functional connectivity between the VS/NAcc and the left orbitofrontal cortex.
  • This connectivity was dependent on the ruminative state.

Conclusions:

  • Ruminative tendencies are associated with altered VS/NAcc function related to reward processing.
  • Findings support the view of rumination as a habitual impairment in selecting adaptive, rewarding strategies.
  • This highlights a potential neural mechanism underlying the link between rumination and depressive states.