Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

5.4K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.4K
Overview of Exosomes01:36

Overview of Exosomes

3.4K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.4K
Extracellular Matrix01:26

Extracellular Matrix

5.0K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
5.0K
Adult Stem Cells01:33

Adult Stem Cells

33.3K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phenotype-specific muscle proteomic profiling in titinopathies.

Acta neuropathologica communications·2026
Same author

Guidelines for Comparing Circular Dichroism Spectroscopy and Molecular Dynamics Simulations for Biomolecules.

Chemphyschem : a European journal of chemical physics and physical chemistry·2026
Same author

Non-destructive pipeline for analysis of crystalline solid dispersions.

International journal of pharmaceutics·2026
Same author

Intracranial and Peripheral Inflammatory Biomarkers Predict Futile Recanalization After Endovascular Treatment.

Stroke·2026
Same author

Proximity-Induced Transfer of a Mass Tag Enables Direct Profiling of Active Matrix Metalloproteases.

Angewandte Chemie (International ed. in English)·2026
Same author

Generation of BBSOAS patient-specific induced pluripotent stem cell lines harboring six NR2F1 pathogenic variants.

Stem cell research·2026

Related Experiment Video

Updated: Dec 26, 2025

Preparation of Plasma Membrane Vesicles from Bone Marrow Mesenchymal Stem Cells for Potential Cytoplasm Replacement Therapy
09:34

Preparation of Plasma Membrane Vesicles from Bone Marrow Mesenchymal Stem Cells for Potential Cytoplasm Replacement Therapy

Published on: May 18, 2017

7.9K

Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging.

Jérémy Boulestreau1, Marie Maumus1, Pauline Rozier1

  • 1Institute of Regenerative Medicine and Biotherapies (IRMB), University of Montpellier, INSERM, Montpellier, France.

Frontiers in Cell and Developmental Biology
|March 11, 2020
PubMed
Summary

Cellular senescence and extracellular vesicles (EVs) from mesenchymal stem/stromal cells (MSCs) contribute to aging. This review explores MSC-derived EVs

Keywords:
agingclinical translationextracellular vesiclesmesenchymal stem cellsregenerative medicinesenescence

More Related Videos

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
07:03

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells

Published on: September 23, 2022

2.5K
A Simple Benchtop Filtration Method to Isolate Small Extracellular Vesicles from Human Mesenchymal Stem Cells
09:10

A Simple Benchtop Filtration Method to Isolate Small Extracellular Vesicles from Human Mesenchymal Stem Cells

Published on: June 23, 2022

1.9K

Related Experiment Videos

Last Updated: Dec 26, 2025

Preparation of Plasma Membrane Vesicles from Bone Marrow Mesenchymal Stem Cells for Potential Cytoplasm Replacement Therapy
09:34

Preparation of Plasma Membrane Vesicles from Bone Marrow Mesenchymal Stem Cells for Potential Cytoplasm Replacement Therapy

Published on: May 18, 2017

7.9K
Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
07:03

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells

Published on: September 23, 2022

2.5K
A Simple Benchtop Filtration Method to Isolate Small Extracellular Vesicles from Human Mesenchymal Stem Cells
09:10

A Simple Benchtop Filtration Method to Isolate Small Extracellular Vesicles from Human Mesenchymal Stem Cells

Published on: June 23, 2022

1.9K

Area of Science:

  • Gerontology and Cellular Biology
  • Focuses on the biological mechanisms of aging and cellular senescence.

Background:

  • Aging is linked to chronic degenerative diseases and involves cellular senescence, characterized by altered proliferation, apoptosis resistance, and a senescence-associated secretory phenotype (SASP).
  • SASP, comprising inflammatory factors and proteases, disrupts tissue homeostasis.
  • Extracellular vesicles (EVs) from senescent cells and age-related changes in mesenchymal stem/stromal cells (MSCs) are implicated in aging's adverse effects.

Purpose of the Study:

  • To review the characteristics and role of EVs derived from senescent MSCs.
  • To examine the impact of MSC-derived EVs on aging processes.
  • To discuss the therapeutic potential of MSC-derived EVs for age-related diseases.

Main Methods:

  • Literature review focusing on cellular senescence, extracellular vesicles, and mesenchymal stem/stromal cells in aging.
  • Analysis of studies investigating the composition and function of EVs from senescent MSCs.
  • Synthesis of evidence regarding the role of MSC-derived EVs in age-related tissue dysfunction and disease.

Main Results:

  • Senescent MSCs release EVs with altered molecular cargo, influencing the tissue microenvironment.
  • MSC-derived EVs can promote or mitigate aging phenotypes depending on their senescence status.
  • Age-related alterations in MSC function impact EV production and signaling.

Conclusions:

  • EVs from senescent MSCs are key mediators of aging phenotypes and tissue dysfunction.
  • Targeting MSC-derived EVs offers a promising therapeutic strategy for age-related diseases.
  • Further research into MSC-EV biology is crucial for developing effective anti-aging interventions.