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Proteome data of serum samples from patients with schizophrenia
T V Butkova1, A T Kopylov1, A A Stepanov1
1V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
Abstract:
Schizophrenia is a complex chronic disease. The molecular determinants and neuropathology of schizophrenia are multifaceted; an important role in the pathogenesis is played by the dysregulation of molecular and epigenetic mechanisms. However, the molecular mechanisms of the development of the disease have not yet been studied. An important task is the accumulation and systematization of "OMICS"-knowledge of the molecular profiles (transcriptome, proteome, metabolome) of blood specific to pathology. Thereby the development and improvement of mass spectrometric methods for the detection of biological molecules has become increasingly important in biomedical research. In the field of applied problems in biomedical research, the most prevalent issue involves the identification of serological protein markers associated with the development of schizophrenia, which account for the diseases that cause the a life-shortening illness, disability, decreased of functioning and quality of life and wellbeing or health status. OMICS approaches are designed to detect genes (genomics), mRNA (transcriptomics), proteins (proteomics) and metabolites (metabolomics) in a specific biological sample. We report the proteomic datasets on the serum samples from patients with schizophrenia (series "SCZ") and healthy volunteers (series "CNT"). Data were acquired using shotgun ultra-high resolution mass spectrometry.
Insights
This study explores the proteomic profiles in schizophrenia patients
Area of Science:
- Neuroscience
- Biochemistry
- Genetics
Background:
- Schizophrenia is a complex chronic brain disorder with poorly understood molecular mechanisms.
- Dysregulation of molecular and epigenetic factors plays a role in schizophrenia pathogenesis.
- Identifying specific molecular markers is crucial for understanding and potentially treating schizophrenia.
Purpose of the Study:
- To investigate the proteomic differences in serum samples between individuals with schizophrenia and healthy controls.
- To contribute to the accumulation and systematization of "OMICS" data for schizophrenia research.
- To advance the understanding of molecular determinants in schizophrenia development.
Main Methods:
- Utilized shotgun ultra-high resolution mass spectrometry for proteomic analysis.
- Analyzed serum samples from patients diagnosed with schizophrenia (SCZ series).
- Compared proteomic data with serum samples from healthy volunteers (CNT series).
Main Results:
- Generated comprehensive proteomic datasets for schizophrenia patients and healthy controls.
- Established a foundation for identifying serological protein markers associated with schizophrenia.
- Highlighted the importance of mass spectrometry in detecting biological molecules for biomedical research.
Conclusions:
- The study provides valuable proteomic datasets for further research into schizophrenia.
- Advances the identification of potential protein biomarkers for schizophrenia.
- Emphasizes the role of OMICS approaches in unraveling complex disease mechanisms.
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