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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Biological Effects of Radiation02:59

Biological Effects of Radiation

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All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
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Radiation: Applications01:17

Radiation: Applications

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The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
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Mutations01:35

Mutations

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Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
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Related Experiment Video

Updated: Dec 26, 2025

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
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Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis

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Acute Radiation Therapy-related Dermatitis.

Laura Bolton1

  • 1Adjunct Associate Professor, Department of Surgery, Robert Wood Johnson Medical School, New Brunswick, NJ.

Wounds : a Compendium of Clinical Research and Practice
|March 11, 2020
PubMed
Summary

Topical corticosteroids and silver sulfadiazine cream are recommended for managing acute radiation dermatitis (ARD) in breast cancer patients undergoing radiation therapy (RT). These treatments aim to alleviate symptoms and prevent treatment interruptions.

Area of Science:

  • Oncology
  • Dermatology
  • Radiotherapy

Background:

  • Radiation therapy (RT) for breast cancer reduces mortality but frequently causes acute radiation dermatitis (ARD).
  • ARD symptoms like erythema and desquamation can interrupt RT, impacting quality of life and cancer outcomes.
  • ARD differs from chronic radiation dermatitis, which presents long-term effects like fibrosis and atrophy.

Purpose of the Study:

  • To review evidence for topical corticosteroid and 1% silver sulfadiazine (SSD) cream interventions for ARD in breast cancer patients.
  • To highlight guideline-recommended treatments for preventing and managing ARD during RT.

Main Methods:

  • Review of evidence-based guidelines for ARD prevention and treatment.
  • Focus on topical interventions: corticosteroids and 1% silver sulfadiazine (SSD) cream.

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  • Analysis of studies supporting these interventions for breast cancer patients undergoing RT.

    • Main Results:

    • Corticosteroids are recommended for ARD-related discomfort and itching.
    • 1% silver sulfadiazine (SSD) cream is recommended to reduce ARD severity scores.
    • Both interventions are supported by evidence for managing ARD during RT.

    Conclusions:

    • Topical corticosteroids and SSD cream are evidence-based interventions for managing ARD in breast cancer patients.
    • Effective ARD management is crucial for maintaining RT adherence and improving patient outcomes.
    • Guidelines recommend these topical treatments to mitigate ARD's impact on patients undergoing RT.