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Updated: Dec 26, 2025
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Assessing the Secretory Capacity of Pancreatic Acinar Cells
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Measures of Secretory Activation for Research and Practice: An Integrative Review
Clarisa Medina Poeliniz1, Janet L Engstrom2, Rebecca Hoban3,4
1College of Nursing, Rush University, Chicago, Illinois.
Summary
Maternal perception of milk coming in (MP) is a feasible, but unvalidated, measure of early lactation. Measuring milk volume patterns offers a validated approach for assessing milk production in breastfeeding and pump-dependent mothers.
Area of Science:
- Lactation biology
- Reproductive medicine
- Infant nutrition
Background:
- Maternal concern regarding milk volume is common in early postpartum, impacting the critical secretory activation period.
- Accurate assessment of secretory activation is vital for effective lactation support.
Purpose of the Study:
- To review the biology of secretory activation.
- To evaluate the accuracy and feasibility of published methods for measuring secretory activation.
Main Methods:
- Systematic literature search for secretory activation measures in mothers of term and preterm infants.
- Quantitative synthesis review of 15 selected publications, assessing accuracy and feasibility.
- Evaluation criteria included validation against other measures and practical aspects like accessibility and cost.
Main Results:
- Maternal perception of milk coming in (MP) is highly feasible but lacks established accuracy.
- Patterns of increase in maternal milk volume are validated against milk biomarkers and have published normal values.
- Maternal milk biomarkers are accurate standards but currently lack feasibility for routine clinical use.
Conclusions:
- Measures of secretory activation can personalize lactation care by aligning diagnostic tools with maternal risk.
- Future priorities include validating MP as a screening tool, implementing milk volume pattern assessment, and developing point-of-care biomarkers.
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