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Updated: Dec 26, 2025
Myelin Oligodendrocyte Glycoprotein MOG35-55 Induced Experimental Autoimmune Encephalomyelitis EAE in C57BL/6 Mice
Published on: April 15, 2014
A case of MOG encephalomyelitis with T- cell lymphoma
Young Nam Kwon1, Jiwon Koh2, Yoon Kyung Jeon2
1Department of Neurology, Seoul National University Hospital, Seoul, Korea; Department of Neurology, The Catholic University of Korea, Eunpyeong St. Mary's Hospital, Seoul, Korea; Department of Medicine, Graduate School Kyung Hee University, Seoul, Korea.
Background:
Myelin oligodendrocyte glycoprotein immunoglobulin-G (IgG)-associated encephalomyelitis (MOG-EM) is a distinct inflammatory demyelinating disease. We present an unusual MOG-EM cases with concomitant T-cell lymphoma.
Case Report:
A 38-year-old Caucasian male presented with bilateral optic neuritis and multifocal transverse myelitis. He tested positive for MOG-IgG1 and his neurologic symptoms improved with high dose steroid treatment. Six months after his first MOG-EM symptoms, he developed ulcerative skin lesions on his leg and was diagnosed with primary cutaneous γδ T-cell lymphoma. The immunohistochemistry study, performed on his cancer tissue, was negative for MOG.
Conclusion:
Diagnosis of MOG-EM can be considered in patients with concomitant hematologic malignancy, which might be associated with the dysregulated adaptive immunity rather than the direct presentation of the onconeural antigen by cancer. Further studies need to be conducted for the risks and incidence of malignancy in a larger cohort of MOG-EM.
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