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Interaction Between Circadian Rhythms, Energy Metabolism, and Cognitive Function.
Mariano Ruiz-Gayo1, Nuria D Olmo1
1Department of Health and Pharmaceutical Sciences, School of Pharmacy, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain.
Current Pharmaceutical Design
|March 12, 2020
Summary
High-fat diets (HFDs) disrupt meal timing and negatively impact cognition in rodents. Restoring a standard eating pattern can reverse these cognitive deficits, suggesting a link between diet, circadian rhythms, and brain function.
Area of Science:
- Chronobiology
- Neuroscience
- Nutritional Science
Background:
- Circadian rhythms, regulated by light and meal timing, influence sleep, endocrine activity, and cognitive function.
- Cognitive performance exhibits circadian variations, linked to energy needs and feeding behavior.
- Disruptions in circadian rhythms and feeding habits are associated with cognitive decline.
Purpose of the Study:
- To review studies on the effects of high-fat diets (HFDs) on cognitive behavior.
- To examine the influence of HFD-induced circadian alterations on cognition, particularly hippocampus-dependent functions.
Main Methods:
- Review of experimental studies investigating the impact of HFDs on rodent behavior.
- Analysis of research focusing on the relationship between feeding patterns, circadian rhythms, and cognitive processes.
- Examination of studies exploring the effects of HFDs on hippocampus-dependent cognition.
Main Results:
- HFDs alter the circadian distribution of meals in rodents.
- HFDs negatively affect cognitive functions and behavioral motivation.
- Cognitive deficits induced by HFDs are reversible when animals adhere to a standard temporal eating pattern.
Conclusions:
- A strong relationship exists between nutritional factors, chronobiology, and cognition.
- HFDs can disrupt circadian rhythms, leading to cognitive impairments.
- Chronobiological alterations induced by HFDs significantly impact hippocampus-dependent cognition.
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