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Related Concept Videos

Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
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Detection of Mesenteric Tumor Using Dynamic Contrast Enhanced MRI.

Russell N Low1, Robert M Barone2, Bridgette Duggan3

  • 1Department of Radiology, Sharp Memorial Hospital, San Diego, CA, USA. rlow52@yahoo.com.

Annals of Surgical Oncology
|March 12, 2020
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Summary
This summary is machine-generated.

Dynamic contrast-enhanced (DCE) MRI significantly improves the detection of mesenteric peritoneal metastases compared to conventional MRI. This novel technique enhances diagnostic accuracy for identifying tumor spread in the mesentery.

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Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging

Background:

  • Mesenteric peritoneal metastases pose diagnostic challenges.
  • Conventional MRI has limitations in detecting small-volume tumors.

Purpose of the Study:

  • To evaluate dynamic contrast-enhanced (DCE) MRI for detecting mesenteric peritoneal metastases.
  • To compare the efficacy of DCE MRI against conventional MRI in identifying tumor spread.

Main Methods:

  • Thirty-four patients underwent preoperative conventional MRI and DCE MRI.
  • DCE MRI involved rapid imaging sequences over 6 minutes.
  • Parametric maps of tumor vascularity were generated from DCE images.
  • Oncologic surgeons and a radiologist reviewed images, comparing conventional MRI with DCE MRI plus parametric maps.

Main Results:

  • DCE MRI demonstrated superior sensitivity (100%) and accuracy (97%) for upper and lower mesenteric tumors compared to conventional MRI.
  • The addition of DCE MRI improved the accuracy of the Peritoneal Cancer Index (PCI) by over 10% in 46% of patients.
  • DCE MRI significantly improved the accuracy of regional PCI calculations in specific areas.

Conclusions:

  • DCE MRI is a valuable novel contrast tool for enhancing the detection of mesenteric tumors.
  • This technique offers improved visualization of small-volume mesenteric tumors over conventional MRI.